COMPARATIVE EFFECTS OF 2 CHEMOTHERAPEUTIC MOUTHRINSES ON THE DEVELOPMENT OF SUPRAGINGIVAL DENTAL PLAQUE AND GINGIVITIS1,2
- Overholser CD, Meiller TF, DePaola LG, Minah GE, Niehaus C. Comparative effects of 2 chemotherapeutic mouthrinses on the development of supragingival dental plaque and gingivitis. J Clin Periodontol. 1990;17:575-579.
Determine the efficacy of 2 mouthrinses—LISTERINE® Antiseptic and Peridex™—used as supplements to regular oral hygiene measures in reducing supragingival dental plaque and gingivitis (N=124).
Double-blind, controlled, parallel design clinical study of healthy male and female subjects (aged ≥21 years) with preexisting plaque and gingivitis but without evidence of periodontitis.
At 6 months, gingivitis development was inhibited by 35.9% in the LISTERINE® Antiseptic group and by 30.5% in the Peridex™ group, when compared to the hydroalcohol control (P<0.001).
At 6 months, gingivitis development—in posterior regions—was inhibited by 33.2% and 34.4% in the LISTERINE® Antiseptic group and by 26.6% and 33.8% in the Peridex™ group, when compared to the hydroalcohol control (P<0.001).2
LISTERINE® Antiseptic produces gingivitis reductions comparable to Peridex™ at 6 months (including gingivitis in posterior regions).